‘Lithuanian’ Mutation Finally Found in Lithuania

Has Ly6G finally found a job?

In this issue of Blood, Wang et al reveal that ligation of Ly6G on murine neutrophils inhibits neutrophil recruitment, providing the first evidence of a function for this molecule.

Has excimer coronary laser angioplasty finally found a niche?

Selective allodepletion: have we finally found the holy grail?

Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment option for patients with hematologic malignancies and nonmalignant disorders of hematopoiesis. Outcomes of allogeneic HSCT have improved steadily over the decades [1]. However, significant challenges remain. One of these challenges is the so-called Holy Grail of stem cell transplantation immunology: to...

COL1A1 mutation analysis in Lithuanian patients with osteogenesis imperfecta.

Osteogenesis imperfecta (OI) is a generalised disorder of connective tissue characterised by an increased fragility of bones and also manifested in other tissues containing collagen type I, by blue sclera, hearing loss, dentinogenesis imperfecta, hyperextensible joints, hernias and easy bruising. OI is dominantly inherited and results in >90% OI cases, caused by mutations in one of the two gene...

p27/Kipl Mutation Found in Breast Cancer1

The p27/Kipl protein belongs to the recently identified family of pro teins called cyclin-dependent kinase inhibitors. These proteins play an important role as negative regulators of cell cycle-dependent kinase ac tivity during progression of the cell cycle. Since cyclin-dependent kinase inhibitors can inhibit cell proliferation, they may have a role as tumor suppressor genes. To determine whet...